HIV-infections are difficult to control because the virus is in a sort of dormant form, and they can hide in cells. In Nature this week, describes a way to awaken dormant viruses bullying, so they can still be addressed.
With an HIV infection now life is to be reasonable. Thanks to HAART therapy, the virus can be controlled quite well. But the virus is still not completely eradicate succeed. One of the reasons is that the virus is in a dormant form may hide in the cells of the immune system. The immune system itself to these cells can not see that they are infected and therefore dangerous.
Even with medication, the virus in this form not to fight. Meanwhile, dormant viruses that ticking time bombs, which at any time yet again become active, self-replicate and then go through the rest of the body. Therefore HIV patients will their lifetime virus-suppressing drugs to swallow.
In Nature this week, described how the dormant virus may still be tackled. American doctors in eight HIV-infected people the inactive viruses as it were awakened by the drug Vorinostat. This drug is normally used for certain types of lymphoma. It interferes with the genetic activity of cells. In the case of HIV converts the’t virus to encourage it to make copies of itself.
Where upon cells infected with the virus no longer unrecognizable. That Vorinostat and similar agents may activate dormant HIV viruses was previously already demonstrated using cultured cells in laboratories. But something does not guarantee that it works if you have the medicine to a person. The human body is finally a bit more complex than single cells in a Petri dish. That in this case the drug is doing what on the basis of experiments in the laboratory was expected is good news.
Moreover, the agent in the treated patients is even better by having worked than in the loose celkweekjes in the lab. Yet there is no immediate reason to cheer, the doctor writes Steven Deeks in an accompanying commentary. The study of Nature proves that you idle; hidden HIV viruses can potentially deal with a "shock and kill" method.
The shock-section is now succeeded: thats the part where the viruses are awakened. But this does not automatically ensure that the viruses are also slain, either by the immune system or through other medications. The most that can prevent the virus will infect new cells active, that is what the HAART therapy does.
Vorinostat also made sure that not all dormant HIV viruses in the patients were active. Only if all dormant viruses can be awakened and then cleaned up, it is possible for anyone really to cure HIV. Furthermore Vorinostat is not very pleasant drug. It can have many serious side effects, and even an outright poison are. It affects not only on the genetic activity of the virus, but also that of normal cells.
Investigations Nature is an important proof of principle. It opens the way to a new way to tackle HIV. For example, it may be that an agent that is similar to Vorinostat, but just slightly different technique, the viruses effectively activate. And it is a matter of the viruses as long or as often bullying, that no viruses remain dormant, and the infection can be completely removed.
With an HIV infection now life is to be reasonable. Thanks to HAART therapy, the virus can be controlled quite well. But the virus is still not completely eradicate succeed. One of the reasons is that the virus is in a dormant form may hide in the cells of the immune system. The immune system itself to these cells can not see that they are infected and therefore dangerous.Even with medication, the virus in this form not to fight. Meanwhile, dormant viruses that ticking time bombs, which at any time yet again become active, self-replicate and then go through the rest of the body. Therefore HIV patients will their lifetime virus-suppressing drugs to swallow.
In Nature this week, described how the dormant virus may still be tackled. American doctors in eight HIV-infected people the inactive viruses as it were awakened by the drug Vorinostat. This drug is normally used for certain types of lymphoma. It interferes with the genetic activity of cells. In the case of HIV converts the’t virus to encourage it to make copies of itself.
Where upon cells infected with the virus no longer unrecognizable. That Vorinostat and similar agents may activate dormant HIV viruses was previously already demonstrated using cultured cells in laboratories. But something does not guarantee that it works if you have the medicine to a person. The human body is finally a bit more complex than single cells in a Petri dish. That in this case the drug is doing what on the basis of experiments in the laboratory was expected is good news.
Moreover, the agent in the treated patients is even better by having worked than in the loose celkweekjes in the lab. Yet there is no immediate reason to cheer, the doctor writes Steven Deeks in an accompanying commentary. The study of Nature proves that you idle; hidden HIV viruses can potentially deal with a "shock and kill" method.
The shock-section is now succeeded: thats the part where the viruses are awakened. But this does not automatically ensure that the viruses are also slain, either by the immune system or through other medications. The most that can prevent the virus will infect new cells active, that is what the HAART therapy does.
Vorinostat also made sure that not all dormant HIV viruses in the patients were active. Only if all dormant viruses can be awakened and then cleaned up, it is possible for anyone really to cure HIV. Furthermore Vorinostat is not very pleasant drug. It can have many serious side effects, and even an outright poison are. It affects not only on the genetic activity of the virus, but also that of normal cells.
Investigations Nature is an important proof of principle. It opens the way to a new way to tackle HIV. For example, it may be that an agent that is similar to Vorinostat, but just slightly different technique, the viruses effectively activate. And it is a matter of the viruses as long or as often bullying, that no viruses remain dormant, and the infection can be completely removed.
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